Reference
Scientific publications and presentations
McElhaney, J.E., Simor, A.E., McNeil, S., Predy, G.N.( 2011) Efficacy and Safety of CVT-E002, aProprietary Extract of Panax quinquefolius in the Prevention of Respiratory Infections in Influenza-Vaccinated Community-Dwelling Adults: A Multicenter, Randomized, Double-Blind and Placebo-Controlled Trial. Influenza Research and Treatment; Article ID 759051.
Wei, H.Y., Jiahua, W., Wong, T., Shan, J.J., Ling, L., Donghai, H. (2011) Determination of main ginsenoside contents in American and Chinese ginsengs using NIR spectroscopy. Abstract and presentation at the 8th Annual Natural Health Products Research Society of Canada Research Conference, Montreal, Quebec, May 24-27.
Ebeling, C., Gordon, J.R., Adamko, D.J., Rittenbach, K.A., Lutsiak, C., Sutherland, S.K., Shan, J.J. (2011) Immunomodulatory and anti-allergy effects of CVT-E002, a patented proprietary extract of North American ginseng. Abstract and presentation at the 8th Annual Natural Health Products Research Society of Canada Research Conference, Montreal, Quebec, May 24-27.
Lewanczuk, R.Z., Udani, J., Goel, V., Narine, K., Ling, L., Sutherland, S.K., Shan, J.J. (2011) Lipid-lowering effects of DilexaponanTM (LIP-01), a proprietary formulation consisting of Coptis chinensis and Ilex Kudingcha extracts. Abstract and presentation at the 8th Annual Natural Health Products Research Society of Canada Research Conference, Montreal, Quebec, May 24-27.
Wang, M., Goel, V., Wang, S., Ling, L., Shan, J.J. (2011) Immune stimulating effects of Immunity-FXTM in cultured cells. Abstract and presentation at the 8th Annual Natural Health Products Research Society of Canada Research Conference, Montreal, Quebec, May 24-27.
Miller, S.C., Ti, L., Shan, J.J. (2011) Short term exposure of adult and juvenile mice to a proprietary extract of North American ginseng results in long term, quantitative changes in the hemopoietic and immune cells of the spleen, bone marrow and blood. Abstract and presentation at the 8th Annual Natural Health Products Research Society of Canada Research Conference, Montreal, Quebec, May 24-27.
Udani, J., Lewanczuk, R.Z. Goel, V., Narine, K., Ling, L., Sutherland, S., Shan, J.J. (2011) DilexaponanTM, (LIP-01), a proprietary formulation consisting of multiactive components extracted from Coptis chinensis and Ilex Kudingcha, demonstrates lipid-lowering effects in pre-clinical and clinical studies. Abstract and presentation at the Scripps 8th Annual Natural Supplements: An Evidence-Based Update, January 13-16.
Miller, S.C., Delorme, D., Shan, J.J. (in press) A proprietary extract of North American ginseng (Panax quinquefolius) administered to leukemic, juvenile mice extends their life span in a dose-dependent manner. Journal of Complementary & Integrative Medicine.
Ilarraza, R., Wu, Y., Davoine, F., Adamko, D. (in press) Human dendritic cells generate a Th1-type response when stimulated by CVT-E002. Journal of Pharmacy and Pharmacology.
Miller, S.C., Ti, L., Shan, J.J. (2010) Immunostimulation of Natural Killer (NK) cells by North American ginseng in adult and juvenile mice: Short term exposure produces long term effects. . Abstract and presentation at the 7th International Conference of the Society for Integrative Oncology, New York, NY, November 11-13.
High, K.P., Case, D., Siegel, R., Metzner-Sadurski, J., Krauss, J., Chinnasami, B., Sanders, G., Rousey, S., Lesser, G., Shaw, E. (2010) A phase III randomized, double-blind, placebo-controlled trial of North American ginseng (Panax quinquefolius) extract (CVT-E002) in patients with chronic lymphocytic leukemia (CLL): effect on respiratory infections and antibiotic use. Abstract and presentation at the 7th International Conference of the Society for Integrative Oncology, New York, NY, November 11-13.
Sutherland, S.K., Lutsiak, C., Ling, L., Shan, J.J. (2010) Botanical Drug Discovery from Traditional Ingredients- Polymolecular Therapeutic Opportunities. Abstract and presentation at the Ontario Ginseng Innovation and Research Consortium Second Joint Conference, Ottawa, Ontario, October 23-25.
Lewanczuk, R.Z., Udani, J., Goel, V., Narine, K., Ling, L., Sutherland, S., Shan, J.J. (2010) Lipid-modulating effects of a proprietary formulation, DilexaponanTM (LIP-01), consisting of multiactive compounds extracted from Coptis chinensis and Ilex kudingcha. Abstract and presentation at the Canadian Cardiovascular Congress, Montreal, Quebec, October 23-27.
High, K.P., Case, L.D., Siegel, R.D., Metzner-Sadurski, J., Krauss, J.C., Chinnasami, B., Sanders, G.H., Rousey, S., Lesser,G.J., Shaw, E.G. (2010) A phase III randomized, double-blind, placebo controlled trial of North American (NA) ginseng (Panax quinquefolium) extract (CVT-E002) in patients with chronic lymphocytic leukemia: Effect on respiratory infection and antibiotic use. Abstract and presentation at the American Society of Clinical Oncology Annual Meeting, Chicago Illinois, June 4-8.
Goel, V., Qi, G., Wong, T., Ling, L., Shan, J.J. (2010) Safety and lipid-lowering efficacy of LIP-1 in experimental animals. Abstract and presentation at the 7th Annual Natural Health Products Research Society of Canada Research Conference, Halifax, Nova Scotia, May 23-26.
MacKenzie, E.M., Rittenbach, K.A., Wang, L.-J., Liu, G.-Z., Shan, J.J., Lai, C.-T. (2010). Effects of HT1001, a North American ginseng extract, on mice with scopolamine-induced amnesia. Abstract and presentation at the 7th Annual Natural Health Products Research Society of Canada Research Conference, Halifax, Nova Scotia, May 23-26.
Purdon, S.E. (2010). Cognitive, emotional and psychosocial effects of HT1001, a North American ginseng extract, in healthy adults: A randomized, double-blind, placebo-controlled clinical trial. Abstract and presentation at the 7th Annual Natural Health Products Research Society of Canada Research Conference, Halifax, Nova Scotia, May 23-26.
Sutherland, S.K., Rittenbach, K.A., Goel, V., Shan, J.J. (2010). Systematic review of randomized, double-blind, placebo-controlled clinical trials of daily dosing of a North American ginseng extract (CVT-E002). Abstract and presentation at the 7th Annual Natural Health Products Research Society of Canada Research Conference, Halifax, Nova Scotia, May 23-26.
Wang, M., Wang, S., Goel, G., Ling, L., Shan, J.J. (2010). Anti-oxidant activity of different herbal extracts used in Traditional Chinese Medicine for the treatment of cardiovascular disease. Abstract and presentation at the 7th Annual Natural Health Products Research Society of Canada Research Conference, Halifax, Nova Scotia, May 23-26.
Wang, S., Goel, V., Qi, G., Wong, T., Ling, L., Shan, J.J. (2010). Lipid-lowering activity of a new Natural Health Product. Abstract and presentation at the 7th Annual Natural Health Products Research Society of Canada Research Conference, Halifax, Nova Scotia, May 23-26.
Wong, T., Ling, L., Shan, J.J., Huang, Y.W., Han, D.H. (2010). Methodologies of ginseng species differentiation. Abstract and presentation at the 7th Annual Natural Health Products Research Society of Canada Research Conference, Halifax, Nova Scotia, May 23-26.
MacKenzie, E.M., Purdon, S.E., Chen, E.Y.H., Lai, C.-T., Sutherland, S.K., Shan, J.J. (2010). Effects of HT1001, a North American ginseng extract, on memory function. Abstract and presentation at the 33rd Annual Meeting of the Canadian College of Neuropsychopharmacology, joint meeting with the Canadian Association for Neuroscience, Ottawa, Ontario, May 14-17.
McElhaney, J. Guilbert, L.J., Reid, D., Lowe, K., Hooten, J., Shan, J.J. (in press). COLD-FX® stimulates cell mediated immune response of peripheral leukocytes ex-vivo to influenza virus in National Hockey League players. The Open Nutraceuticals Journal 3: 25-29.
Sutherland, S.K., Purdon, S.E., Lai, C.-T., Wang, L.-J., Liu, G.-Z., Shan, J.J. (2010) Memory enhancement from two weeks’ exposure to North American ginseng extract HT1001 in young and middle aged healthy adults. The Open Nutaceuticals Journal 3: 20-24.
Purdon, S.E., Chen, E.Y.H., Sutherland, S.K., MacKenzie, E.M., Shan, J.J. (2010). Clinical effects of North American ginseng extract (HT1001) on memory function. Abstract and presentation at the Scripps 7th Annual Natural Supplements: An Evidence-Based Update, San Diego, California, January 21-24.
Sutherland, S.K., Rittenbach, K.A., Goel, V., Shan, J.J. (2010). Systematic review of randomized, double-blind, placebo-controlled clinical trials of daily dosing of a North American ginseng extract (CVT-E002®). Abstract and presentation at the Scripps 7th Annual Natural Supplements: An Evidence-Based Update, San Diego, California, January 21-24.
Miller, S.C., Delorme, D., Shan, J.J. (2009) CVT-E002 Stimulates the Immune System and Extends the Life Span of Mice Bearing a Tumor of Viral Origin. Journal of the Society for Integrative Oncology 7(4): 127-136. PM:19883528
Miller, S.C., Delorme, D., Shan, J.J. (2009). A proprietary extract of North American ginseng (Panax quinquefolius) administered to leukemic, juvenile mice extends their life span in a dose-dependent manner. Abstract and presentation at the 6th Annual Meeting of the Society of Integrative Oncology, New York, New York, November 12-13.
Purdon, S.E., Purdon, T.L.L., Nguyen-Burns, A., Lai, C.-T. (2009). Acute treatment effects of double-blind placebo-controlled Panax Quinquefolium L (REMEMBER-FX®) on mental alertness, sustained attention, and working memory. Abstract and presentation at the 5th Annual Canadian Conference on Dementia, Toronto, Ontario, October 1-3.
Ilarraza, R., Wu, Y., Davoine, F., Adamko, D. (2009). CVT-E002, a Polysaccharide from North American ginseng (Panax quinquefolium) enhances immune response in a human dendritic and T cell co-culture model. Abstract and presentation at the American Thoracic Society International Conference, May 15-20.
Ebeling, C., Wu, Y., Adamko, D.J. (2009). CVT-E002, a Polysaccharide from North American Ginseng (Panax quinquefolium) reduces allergic immune response and development of airway reactivity in a mouse model of asthma. Abstract and presentation at the Annual Meeting of the American Academy of Allergy Asthma & Immunology, Washington DC, March 13-17.
Newton, J., Patrick, A., Rosenthal, K.L. (2009). CVT-E002 activates human innate immune responses via selected Toll-like receptors. Abstract and presentation at the 6th Natural Health Products Research Conference, Vancouver, British Columbia, February 18-21.
Rittenbach, K., Ilarraza, R., Wu, Y., Davoine, F., Adamko, D.J. (2009). CVT-E002, a Polysaccharide from North American Ginseng (Panax quinquefolium) enhances immune response in a human dendritic and T cell co-culture model. Abstract and presentation at the 6th Natural Health Products Research Conference, Vancouver, British Columbia, February 18-21.
Biondo, P.D., Goruk, S., Ruth, M.R., O’Connell, E., Field, C.J. (2008). Effect of CVT-E002 (COLD-fX) versus a ginsenoside extract on systemic and gut-associated immune function. International Immunopharmacology 8(8): 1134-1142.
Miller, S.C. and Delorme, D. (2008) An extract from North American Ginseng Stimulates Spontaneous Immunity in Infant Mice: Sustained, Augmented Immunity in Adulthood Long after Withdrawal of the Extract. Journal of Complementary and Integrative Medicine 5(1): pp-pp. JCIM
Vohra S, Johnston BC, Laycock KL, Midodzi WK, Dhunnoo I, Harris E, Baydala L. (2008) Safety and tolerability of North American ginseng extract in the treatment of pediatric upper respiratory tract infection: a phase II randomized controlled trial of two dosing schedules. Pediatrics 122: e402-e410. PM:18676527
Rosenthal, K.L., Newton, J., Patrick, A. (2008). CVT-E002, a proprietary extract of North American ginseng, activates the vertebrate innate immune system to produce pro-inflammatory and anti-viral factors via MyD88 signalling. Abstract and presentation at the 95th Annual Meeting of The American Association of Immunologists, San Diego, California, April 5-9.
Adamko, D.J. Wu, Y., Ilarraza, R., Davoine, F. (2008) CVT-E002, a proprietary North American Ginseng extract, increases anti-viral immune responses in an in vitro model of virus-induced asthma exacerbation. Abstract and presentation at the 5th Natural Health Product Research Conference, Toronto, Ontario, March 28.
Newton, J., Patrick, A.J., Rosenthal, K.L. (2008) CVT-E002, a proprietary extract of North American ginseng, activates the vertebrate innate immune system to produce proinflammatory and anti-viral factors via MyD88 signaling. Abstract and presentation at the 5th Natural Health Product Research Conference, Toronto, Ontario, March 28.
Purdon, S.E., Wang, L., Liu, G. (2008). Memory enhancement after two weeks’ exposure to American ginseng extract HT1001 in young and middle aged healthy adults. Abstract and presentation at the 36th Annual International Neuropsychological Society Meeting, Waikoloa, Hawaii, February 6-9.
Shan, J.J., Rodgers, K., Lai, C.-T., Sutherland, S.K. (2007). Challenges in Natural Health Product Research: The Importance of Standardization. Proceedings of the Western Pharmacology Society 50: 24-30 (invited review).
Vohra, S., Johnston, B.C., Laycock, K.L., Midodzi, W.K., Dhunnoo, I., Harris, E., Baydala, L. (2007). Safety and tolerability of North American ginseng extract in the treatment of pediatric upper respiratory tract infection: a phase II randomized controlled trial of two dosing schedules. Abstract and presentation at the 14th Annual Symposium on Complementary Health Care, Exeter, United Kingdom, December 11-13.
Miller, S.C., Delorme, D., Shan, J.J. CVT E002, a proprietary extract of North American ginseng (Panax quinquefolium), stimulates the immune system and significantly extends the life span of leukemic mice: a pre-clinical analysis of the hemopoietic and immune cells in vivo. Abstract and presentation at the 4th International Conference of the Society for Integrative Oncology, San Francisco, California, November 15-17.
Purdon, S.E., Lai, C.T., Wang, L.J., Liu, G.Z. (2007). Memory enhancement from two weeks’ exposure to American ginseng extract HT1001 in young and middle aged healthy adults. Abstract and presentation at the 4th Canadian Colloquium on Dementia, Vancouver, British Columbia, October 18-2.
Lai, C.-T., Sutherland, S.K., Shan, J.J., Chen, E.Y.H. (2007). REMEMBER-fX®(HT1001) improved visual working memory in schizophrenic patients: a double-blind, placebo controlled study. Abstract and presentation at the 30th Annual Meeting for the Canadian College of Neuropsychopharmacology, Banff, Alberta, June 15-18.
Lai, C.-T., Wang, L.-J., Liu, G.-Z., Sutherland, S.K., Shan, J.J. (2007). REMEMBER-fX®(HT1001) improved memory and learning functions in young and middle aged healthy adults: a pilot study. Abstract and presentation at the 30th Annual Meeting for the Canadian College of Neuropsychopharmacology, Banff, Alberta, June 15-18.
Shan, J.J., Lai, C.-T., Sutherland, S.K. (2007). Challenges in natural health product research: the importance of standardization. Abstract and presentation at the 50th Annual Pharmacology and Therapeutics Conference, Banff, Alberta, March 4-8.
McElhaney, J.E., Goel, V., Toane, B., Hooten, J., Shan, J.J. (2006) Efficacy of COLD-fX in the prevention of respiratory symptoms in community dwelling adults: a randomized, double-blind, placebo controlled trial. Journal of Alternative and Complementary Medicine 12(2): 153-157. PM:16566675
Predy, G.N., Goel, V., Lovlin, R. and Basu, T.K. (2006) Immune modulating effects of daily supplementation of COLD-fX (a proprietary extract of North American ginseng) during influenza season in healthy adults. Journal of Clinical Biochemistry and Nutrition 39: 162-167. JCBN 1880-5086
Sutherland, S.K., Shan, J.J. (2005) Antioxidant and Anti-Cancer Properties of Herbal Extracts of North American Ginseng, Ginkgo Biloba and Saint John’s Wort. Abstract and presentation at the 2nd International Conference of the Society for Integrative Oncology, San Diego, CA, November 10-12.
Shan, J.J., Predy, G., Goel, V., Sutherland, S., Basu, T. (2005) COLD-fX®(A Proprietary Extract of Panax Quinquefolius) Prevents Upper Respiratory Infections Due to Colds and Flu in a Susceptible Population. Abstract and presentation at the 2nd International Conference of the Society for Integrative Oncology, San Diego, CA, November 10-12.
Holt, A. and Shan J. (2005) Inhibition of human hepatic cytochrome P450 enzymes by COLD-fX and REMEMBER-fX- proprietary extracts of North American ginseng (Panax Quinquefolium). CAM Health Services and Policy Research in Canada - New Directions: Abstracts from the First Annual IN-CAM Symposium. Journal of Complementary and Integrative Medicine 2(1)(3): 28. JCIM
Predy, G.N., Goel, V., Lovlin, R., Donner, A., Larry, S. and Basu, T.K. (2005) Efficacy of an extract of North American ginseng containing poly-furanosyl-pyranosyl-saccharides for preventing upper respiratory tract infections: a randomized controlled trial. Canadian Medical Association Journal 173(9): 1043-1048. PM:16247099
Goel, D.P., Geiger, J.D., Shan, J.J., Kriellaars, D. and Pierce, G.N. (2004) Doping-control urinalysis of a ginseng extract, COLD-fX, in Athletes. International Journal of Sport Nutrition and Exercise Metabolism 14: 1-8. PM:15467104
McElhaney, J.E., Gravenstein, S., Cole, S.K., Davidson, E., O’Neil, D., Petitjean, S., Rumble, B., and Shan, J.J. (2004) A placebo-controlled trial of proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults. Journal of American Geriatric Society 52:13-19. PM:14687309
Shan, J.J. (2004). The immunological-base of a North American ginseng extract, COLD-fX, for prevention of colds and flu. Abstract and presentation at the 1st Annual Meeting of the Canadian Interdisciplinary Network for Complementary & Alternative Medicine Research, Toronto, Ontario, December 4-5.
Wang, M., Guilbert, L.J., Li, J., Wu, Y., Pang, P., Basu, T.K., Shan, J.J. (2004) A proprietary extract from North American ginseng (Panax quinquefolium) enhances IL-2 and IFN- γ productions in murine spleen cells induced by Con-A. International Immunopharmacology 4(2): 311-315. PM:14996422
Ueng, Y.F and Chen, C.F (2002) Effects of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium) on hepatic drug-metabolizing enzymes in C57BL/6J mice. Journal of Chinese Medicine 13(2): 89-96.
Lyon, M.R., Cline, J.C., Totosy de Zepetnek, J., Shan, J.J., Pang, P., Benishin, C. (2001) Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: a pilot study. Journal of Psychiatry & Neuroscience 26(3): 221-228.
Wang, M., Guilbert, L.J., Ling, L., Li, J., Wu, Y., Xu, S., Pang, P., Shan, J.J. (2001) Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium). Journal of Pharmacy and Pharmacology 53(11):1515-1523. PM:11732754
Yang, J.C., Pang, C.S., Tsang, S.F., Ng, K.F. (2001) Effect of American ginseng extract (Panax quinquefolius) on formaline-induced nociception in mice. American Journal of Chinese Medicine 29(1): 149-154 PM:11321472
McElhaney, J., Guilbert, L., Hooton, J., Pankovich, J., Shan, J.J., Lowe, K., Reid, D. (2001). Summary of studies with COLD-FX in high performance professional athletes assessing the tolerability and outcomes related to cold and flu like symptoms. Abstract and presentation at the 1st International Scientific Congress on Nutrition & Athletic Performance, Edmonton, Alberta, August 8-11.
Sloley, B.D., Pang, P.K.T., Huang, B.H., Li, B.A., Benishin, C.G., Greenshaw, A.J., Shan, J.J. (1999). American ginseng extract reduces scopolamine-induced amnesia in a spatial learning task. Journal of Psychiatry & Neuroscience 24(5): 442-452.